865589-88-4Relevant articles and documents
The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists
Brown, Alan D.,Bunnage, Mark E.,Glossop, Paul A.,James, Kim,Jones, Rhys,Lane, Charlotte A.L.,Lewthwaite, Russell A.,Mantell, Simon,Perros-Huguet, Christelle,Price, David A.,Trevethick, Mike,Webster, Rob
, p. 1280 - 1283 (2008/09/19)
The design and profile of a series of adamantyl-containing long acting β2-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using