865604-20-2Relevant articles and documents
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P.,White, Clara Bantry,Barker, Oliver,Barker, Stephanie,Bennett, James,Brown, David,Boyd, E. Andrew,Brennan, Christopher,Chowdhury, Chandana,Collins, Ian,Convers-Reignier, Emmanuelle,Dymock, Brian W.,Fletcher, Rowena,Haydon, David J.,Gardiner, Mihaly,Hatcher, Stuart,Ingram, Peter,Lancett, Paul,Mortenson, Paul,Papadopoulos, Konstantinos,Smee, Carol,Thomaides-Brears, Helena B.,Tye, Heather,Workman, James,Czaplewski, Lloyd G.
scheme or table, p. 894 - 899 (2009/08/15)
The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency.
IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
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Page/Page column 59, (2008/12/04)
Compounds of Formula (I) in which A, B, R1, R1a, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1
New catalysts for Suzuki-Miyaura coupling reactions of heteroatom- substituted heteroaryl chlorides
Guram, Anil S.,Wang, Xiang,Bunel, Emilio E.,Faul, Margaret M.,Larsen, Robert D.,Martinelli, Michael J.
, p. 5104 - 5112 (2008/02/07)
(Chemical Equation Presented) The new air-stable PdCl2{PR 2(Ph-R′)}2 complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of he
IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS
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Page/Page column 32, (2008/06/13)
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of