865622-24-8

Upstream product

• 657411-69-3 (2S)-2-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentanethioic acid S-pyridin-4-yl ester 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 7733-29-1 Z-Orn(Boc)-OH 
• 18942-74-0 (2S)-2-acryloylamino-4-methylpentanoic acid methyl ester 
• 657411-64-8 (2S)-2-[(5S)-5-benzyloxycarbonylamino-8-tert-butoxycarbonylamino-4-oxo-octanoylamino]-4-methylpentanoic acid methyl ester 

Downstream Products

• 866563-55-5 (2S)-2-[(4R,5S)-8-(2,3-bis(tert-butoxycarbonyl)guanidino)-5-benzyloxycarbonylamino-4-hydroxy-octanoylamino]-4-methylpentanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of a hydroxyethylene isostere of the tripeptide Arg-Gly-Leu via a convergent acyl-like radical addition strategy

A hydroxyethylene isostere of the tripeptide Arg-Gly-Leu, representing an important fragment of a novel cyclic-peptide-based uPA inhibitor, was synthesized in few steps employing as the key step a samarium diiodide promoted coupling of either the 4-thiopy

Further studies in the acyl-type radical additions promoted by SmI 2: Mechanistic implications and stereoselective reduction of the keto-functionality

Attempts were made to promote the carbonyl coupling of cyclohexanone to 4-pyridylthioesters of N-carbamate-protected amino acids with the one electron reducing agent, samarium diiodide. Such reactions proved unsuccessful due to the inability of the ketyl-