865626-73-9Relevant academic research and scientific papers
Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability
Degnan, Andrew P.,Conway, Charles M.,Dalterio, Richard A.,Macci, Robert,Mercer, Stephen E.,Schartman, Richard,Xu, Cen,Dubowchik, Gene M.,Macor, John E.
, p. 3555 - 3558 (2009)
The calcitonin gene-related peptide (CGRP) receptor has been implicated in the pathogenesis of migraine. A class of urethanamide derivatives has been identified as potent inhibitors of the CGRP receptor. Compound 20 was found to be among the most potent (
Novel therapeutic agents for the treatment of migraine
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Page/Page column 30; 32, (2010/02/14)
The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their u
