865705-72-2Relevant academic research and scientific papers
Synthesis of Sulfones via Ru(II)-Catalyzed Sulfination of Boronic Acids
Gulbe, Krista,Turks, Mā ris
, p. 5660 - 5669 (2020)
Ruthenium(II) complexes catalyze the insertion of sulfur dioxide into (het)aryl and alkenyl boronic acids. The transmetalation-sulfination process proceeds with DABSO in the presence of 5 mol % RuCl2(PPh3)3 in methanol at 100 °C. The intermediate sulfinate salt can be quenched with various electrophiles such as alkyl halides, epoxides, Michael acceptors, and λ3-iodanes in moderate to good yields. The reported sulfone synthesis can be performed either as a direct one-pot or one-pot two-step procedure depending on the reactivity of the electrophile.
