865705-90-4Relevant academic research and scientific papers
Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator
Ratni, Hassen,Blum-Kaelin, Denise,Dehmlow, Henrietta,Hartman, Peter,Jablonski, Philippe,Masciadri, Raffaello,Maugeais, Cyrille,Patiny-Adam, Angelique,Panday, Narendra,Wright, Matthew
, p. 1654 - 1657 (2009)
A series of tetrahydro-cyclopenta[b]indoles modulating the activity of the liver-X-receptor (LXR) were derived from a high throughput screening hit. The potency and selectivity for LXRβ versus LXRα was improved. One compound, administered to wild-type mic
