865715-91-9Relevant academic research and scientific papers
Synthesis of macrocyclic urea kinase inhibitors
Tao, Zhi-Fu,Sowin, Thomas J.,Lin, Nan-Horng
, p. 2855 - 2858 (2008/03/13)
An efficient and convergent route was developed for the synthesis of a novel class of urea-based macrocyclic kinase inhibitors. The synthesis is featured with an efficient urea formation by using a key carbamate intermediate and with a smooth ring-closure olefin metathesis. Furthermore, the hydrogenations of the resulting olefins were investigated in this complex macrocyclic ring system. Georg Thieme Verlag Stuttgart.
Macrocyclic kinase inhibitors
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Page/Page column 65, (2010/02/14)
Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
