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Usage

Uses

Used in Pharmaceutical Synthesis:
1-(3-aminopropyl)-4-(2-ethoxyphenyl)piperazine is used as an intermediate for the synthesis of various pharmaceutical compounds, leveraging its unique chemical structure to create a range of medications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(3-aminopropyl)-4-(2-ethoxyphenyl)piperazine is used as a building block for the development of new drugs, thanks to its versatile chemical properties and potential for interaction with biological targets.
Used in Neurological Disorder Treatment:
1-(3-aminopropyl)-4-(2-ethoxyphenyl)piperazine is explored as a dopamine receptor antagonist, which may contribute to the treatment of neurological disorders by modulating the activity of dopamine in the brain.
Used in Antidepressant Development:
Due to its potential binding affinity to serotonin receptors, 1-(3-aminopropyl)-4-(2-ethoxyphenyl)piperazine is investigated for its role in the development of novel antidepressant medications, which could help in the treatment of mood disorders.

Downstream Products

• 111108-27-1 2,5,7-Trimethyl-3-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-propyl]pyrido[2,3-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype- selective antagonists by functional in vitro screening. 3-[4-(ortho- Substituted phenyl)piperazin-1:yl]propylamines were derivatized with N,N- dimethyl anthranilamides, nicotinamides, as well as carboxamides of quinoline, 1,8-naphthyridine, pyrazolo[3,4-b]pyridine, isoxazolo[3,4- b]pyridine, imidazo[4,5-b]pyridine, and pyrazolo[1,5-a]pyrimidines. Strips of rabbit bladder neck were employed as a predictive assay for antagonism in the human lower tract. Rings of rat aorta were used as a 'negative screen' for the test antagonists. Binding to α1-ARs was relatively sensitive to size and electronic features of the arylpiperazine portion of the antagonists and permissive to these features on the heteroaryl carboxamide side. These structure-affinity findings were exploited to produce nicotinamides (e.g. 13ii and 25x) and pyrazolo[3,4-b]pyridines (e.g. 37f and 37y) ligands with nanomolar affinity at the α1-AR subtype prevalent in the human lower urinary tract (pA2 values: 8.8, 10.7, 9.3, and 9.9, respectively) and displaying 2-3 orders of magnitude selectivity over the α(1D)-AR.

An interactive SAR approach to discover novel hybrid thieno probes as ligands for D2-like receptors with affinities in the subnanomolar range

A series of [(phenylpiperazinyl)alkyl]-isoindole-1,3-dione derivatives was synthesized to serve as probes for dopaminergic receptors. Among this series, compound 6a showed the highest affinity towards D4 and D3 receptors with K i values in the low nanomolar range, and D2/D4- and D2/D3-selectivity indices of 72 and 20, respectively. Optimization rounds were adopted and led to the D4-selective ligand thiophene-2-carboxamide 9a with a Ki(D4) value of 0.62 nM, and to its butyl analog, 10a, with Ki(D4) and Ki(D3) values of 0.03 and 0.26 nM, respectively. Docking experiments revealed the importance of the unique D4 residue Arg186 in manipulating the ligands' D4-subtype-receptor selectivity. Copyright