86577-08-4

Basic information

• Product Name: Butanoic acid, 2-(cyclohexylmethylene)-3-oxo-, methyl ester
• CAS NO: 86577-08-4
• Molecular Formula: C12H18O3
• Molecular Weight: 210.273
• Mol File: 86577-08-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-(cyclohexylmethylene)-3-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-(cyclohexylmethylene)-3-oxo-, methyl ester(86577-08-4)
• EPA Substance Registry System: Butanoic acid, 2-(cyclohexylmethylene)-3-oxo-, methyl ester(86577-08-4)

Safety Data

• Hazardous Substances Data: 86577-08-4(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 133657-18-8 5-Cyclohexyl-1,3,7-trimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester 
• 46725-45-5 dimethyl 4,6-dimethylbenzene-1,3-dicarboxylate 

Relevant articles and documents

Synthesis of β-and β,β-substituted Morita-Baylis-Hillman adducts using a two-step protocol

The synthesis of a large number of β-and β,β-substituted keto esters was successful by the use of the Knoevenagel condensation reaction. The stereoselectivity of these reactions was improved by alteration of various substituent groups. Although there were

ACID CATALIZED RING CLOSURE REACTINOS OF ELECTROPHILIC ALKENES

Treatment of α-acyl-α,β-unsaturated ketones with sulfuric acid or dimethylformamide-hydrogen chloride or p-toluenesulfonic acid gave rise to 3-acyl-2-alkyl-4,5-dihydrofurans.Similar cyclization of α-acyl-α,β-unsaturated esters initially afforded 3-alkoxycarbonyl-2-alkyl-4,5-dihydrofurans which were transformed into 2-acylbutanolides on further reaction with sulfuric acid.This acid catalized cyclization is strongly dependent upon the substitution pattern of the electrophilic alkenes, the acid used and reaction conditions.