865783-99-9

Basic information

• Product Name: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)
• Synonyms: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);Briciclib,ON-014185;ON-014185;(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate
• CAS NO: 865783-99-9
• Molecular Formula: C19H23O10PS
• Molecular Weight: 474.418681
• Product Categories: API
• Mol File: 865783-99-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)(865783-99-9)
• EPA Substance Registry System: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate)(865783-99-9)

Safety Data

• Hazardous Substances Data: 865783-99-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, 1-(dihydrogen phosphate) is used as a pharmaceutical agent for its potential inhibitory effects on specific cellular processes. Its unique structure allows it to target and modulate the activity of key proteins involved in cell proliferation and survival, making it a promising candidate for the development of novel therapeutics against various diseases, including cancer.
Used in Chemical Research:
In the field of chemical research, Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, 1-(dihydrogen phosphate) serves as a valuable compound for studying the structure-activity relationships of phenolic compounds and their derivatives. Its synthesis and modification can provide insights into the design and development of new molecules with improved biological activities and selectivity.
Used in Material Science:
Phenol, 2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, 1-(dihydrogen phosphate) can be utilized in material science for the development of novel materials with specific properties. Its unique structure and functional groups can be exploited to create materials with tailored characteristics, such as improved stability, reactivity, or selectivity, for various applications.

Upstream product

• 97315-18-9 p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde 
• 97315-19-0 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl alkohol 
• 865783-96-6 3-[(tert-butyldimethylsilyl)oxy]-4-methoxybenzylthioacetic acid 
• 911294-97-8 3-[(tert-butyldimethylsilyl)oxy]-4-methoxybenzyl chloride 
• 865783-97-7 3-hydroxy-4-methoxybenzylthioacetic acid 
• 865783-98-8 3-hydroxy-4-methoxybenzylsulfonylacetic acid 
• 852283-22-8 (E)-5-((2,4,6-trimethoxystyrylsulfinyl)methyl)-2-methoxyphenol 
• 621-59-0 isovanillin 
• 865784-00-5 (E)-2,4,6-trimethoxystyryl-3-O-bis(benzyl)phosphoryl-4-methoxybenzylsulfone 

Relevant articles and documents

PROCESSES FOR PREPARING (E)-STYRYLBENZYLSULFONE COMPOUNDS AND USES THEREOF FOR TREATING PROLIFERATIVE DISORDERS

Processes for preparing (E)-2,4,6-(Trimethoxystyryl)-3-O-Phosphate Disodium-4-Methoxybenzyl Sulfones and uses thereof as antiproliferative agents, including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

Substituted Phenoxy-and Phenylthio-Derivatives for Treating Proliferative Disorders

Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents

Cell cycle progression is regulated by cyclins and cyclin-dependent kinases, which are formed at specific stages of the cell cycle and regulate the G1/S and G2/M phase transitions, employing a series of "checkpoints" governed by phosphorylation of their substrates. Tumor development is associated with the loss of these checkpoint controls, and this provides an approach for the development of therapeutic agents that can specifically target tumor cells. Here, we describe the synthesis and SAR of a novel group of cytotoxic molecules that selectively induce growth arrest of normal cells in the G1 phase while inducing a mitotic arrest of tumor cells resulting in selective killing of tumor cell populations with little or no effect on normal cell viability. The broad spectrum of antitumor activity in vitro and xenograft models, lack of in vivo toxicity, and drug resistance suggest potential for use of these agents in cancer therapy.