865792-18-3

Usage

Uses

Used in Pharmaceutical Industry:
Cilostazol Related Compound C (50 mg) (1-(4-(5-Cyclohexyl-1H-tetrazol-1-yl)butyl)-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one) is used as an impurity in the production of Cilostazol, a medication used to treat intermittent claudication, a symptom of peripheral arterial disease. Its presence in Cilostazol may contribute to the drug's therapeutic effects or require monitoring and control to ensure safety and efficacy.

Upstream product

• 73963-72-1 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydrocarbostyril 
• 73963-42-5 1-cyclohexyl-5-(4-chlorobutyl)-1,2,3,4-tetrazole 
• 54197-66-9 3,4-dihydro-6-hydroxy-2(1H)-quinolinone 

Relevant academic research and scientific papers

PROCESS FOR PURIFICATION OF CILOSTAZOL

The present invention provides a process for preparing high purity cilostazol. The process comprises: (a) adding crude cilostazol to an acid selected from the group consisting of oxalic acid, maleic acid, sulfuric acid, and a mixture thereof to form a cilostazol salt; and (b) recovering cilostazol through adding a base to the cilostazol salt.

Highly pure cilostazol and an improved process for obtaining same

A novel process for preparing highly pure cilostazol, effected by reacting 6-hydroxy-3,4-dihydroquinolinone and 5-(4-chlorobutyl)-1-cyclohexyl-1H-tetrazole in the presence of a hydrated inorganic base, is disclosed. Further disclosed is highly pure cilostazol, and particularly highly pure cilostazol that is substantially free of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butyl]-3,4-dihydro-1H-quinolin-2-one.