865795-65-9Relevant academic research and scientific papers
Orally bioavailable prodrugs of a BCS class 2 molecule, an inhibitor of HIV-1 reverse transcriptase
Elworthy, Todd R.,Dunn, James P.,Hogg, J. Heather,Lam, Grace,Saito, Y. David,Silva, Tania M.P.C.,Stefanidis, Dimitrios,Woroniecki, Witold,Zhornisky, Eugenia,Zhou, Amy S.,Klumpp, Klaus
, p. 6344 - 6347 (2008)
The N-2 position of pyridazinone 1, a potent HIV-1 NNRTI that has limited aqueous solubility, was derivatized into a series of hydroxymethyl esters and carbonates as well as one phosphate. The derivatives served as prodrugs to effectively deliver 1 to rat
