865871-98-3Relevant academic research and scientific papers
Amino acid bromides: Their N-protection and use in the synthesis of peptides with extremely difficult sequences
DalPozzo, Alma,Ni, Minghong,Muzi, Laura,Caporale, Andrea,De Castiglione, Roberto,Kaptein, Bernard,Broxterman, Quirinus B.,Formaggio, Fernando
, p. 6372 - 6375 (2007/10/03)
Nα-Protected α-amino acid bromides were easily generated in situ with 1-bromo-N,N-2-trimethyl-1-propenylamine from the corresponding amino acids under very mild conditions. o-Nbs and the azido moieties proved to be compatible with these overactivated halides and were successfully applied in difficult peptide bond formations. N-Deprotection methods and the total step-by-step solution synthesis of a peptide containing up to seven consecutive L-(αMe)Valine residues are also reported. The assembly of this homopeptide was achieved in a short time and in very high yields by the azido/bromide system in a single repetitive operation.
