866018-46-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL is used as a chemical intermediate for the synthesis of metabolites of Sertraline, a widely prescribed antidepressant medication. Its role in the synthesis process is crucial for the production of the final drug product, contributing to the treatment of various mental health conditions.

Upstream product

• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 439134-46-0 1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene 

Downstream Products

• 439134-46-0 1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene 
• 96850-13-4 trans-3-(3,4-dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride 
• 944053-83-2 C₁₈H₁₉Cl₂N 
• 944054-51-7 2-(-1-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-3-yl)acetonitrile 
• 944054-52-8 2-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetonitrile 
• 944053-99-0 2-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)ethanamine 
• 944054-68-6 C₂₃H₂₇Cl₂NO₂ 

Relevant academic research and scientific papers

Sodium amalgam mediated desulfonylative reduction of α-functionalized β-ketosulfones

Sodium amalgam mediated desulfonylative reduction of β-ketosulfones in MeOH at rt affords alcohols in good yields via radical desulfonylation of β-ketosulfones and sequential Bouveault-Blanc reduction of the resulting ketones.

Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N- methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors

The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activi

Iodine(III)-promoted ring contraction of 1,2-dihydronaphthalenes: A diastereoselective total synthesis of (±)-indatraline

Equation presented A new approach for the synthesis of (±)- indatraline, which is a 3-phenyl-1-indanamine that displays several biological activities, is described. The strategy features as the key step a diastereoselective ring contraction of a 1,2-dihydronaphthalene promoted by Phl(OTs)OH, to construct the indan ring system. The oxidative rearrangement of other 1,2-dihydronaphthalenes was also investigated, generalizing this method to obtain indans.

Efficient kinetic resolution in hydroboration of 1,2-dihydronaphthalenes

1-Substituted 1,2-dihydronaphthalenes undergo kinetic resolution during asymmetric hydroboration with Rh-QUINAP complexes.