866019-12-7

Basic information

• Product Name: 2-[2-(4-METHOXYPHENYL)-2-OXOETHOXY]BENZENECARBOXAMIDE
• Synonyms: 2-[2-(4-METHOXYPHENYL)-2-OXOETHOXY]BENZENECARBOXAMIDE;2-[2-(4-methoxyphenyl)-2-oxoethoxy]benzamide
• CAS NO: 866019-12-7
• Molecular Formula: C₁₆H₁₅NO₄
• Molecular Weight: 285.29
• Mol File: 866019-12-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[2-(4-METHOXYPHENYL)-2-OXOETHOXY]BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4-METHOXYPHENYL)-2-OXOETHOXY]BENZENECARBOXAMIDE(866019-12-7)
• EPA Substance Registry System: 2-[2-(4-METHOXYPHENYL)-2-OXOETHOXY]BENZENECARBOXAMIDE(866019-12-7)

Safety Data

• Hazardous Substances Data: 866019-12-7(Hazardous Substances Data)

Upstream product

• 65-45-2 salicylamide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 866019-32-1 3-(4-methoxyphenyl)-1,4-benzoxazepin-5(4H)-one 
• 866050-77-3 3-(4-methoxyphenyl)-3,4-dihydrobenzo[f ][1,4]oxazepin-5(2H)-one 

Relevant articles and documents

Synthesis and tranquillizing effect of new 1,4-benzoxazepines

A SERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4-benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the corresponding 1,4-benzoxazepine-5(4H)-thiones. N-alkylation of the 1,4-benzoxazepin-5(4H)-ones and S-alkylation of the 1,4-benzoxazepine-5(4H)-thiones were described. Some of the new compounds were subjected to preliminary screening for their tranquilizing effect.

Synthesis and tranquillizing effect of new 1,4- benzoxazepines

A SERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4- benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the

ISOQUINOLIN-1 (2H) -ONE DERIVATIVES AS PARP-1 INHIBITORS

There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP- ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore usefu