86602-76-8

Basic information

• Product Name: 1,5-Benzothiazepine, 2-(4-bromophenyl)-2,3-dihydro-4-phenyl-
• CAS NO: 86602-76-8
• Molecular Formula: C21H16BrNS
• Molecular Weight: 394.335
• Mol File: 86602-76-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,5-Benzothiazepine, 2-(4-bromophenyl)-2,3-dihydro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Benzothiazepine, 2-(4-bromophenyl)-2,3-dihydro-4-phenyl-(86602-76-8)
• EPA Substance Registry System: 1,5-Benzothiazepine, 2-(4-bromophenyl)-2,3-dihydro-4-phenyl-(86602-76-8)

Safety Data

• Hazardous Substances Data: 86602-76-8(Hazardous Substances Data)

Upstream product

• 40358-31-4 2,3-dihydro-2,4-diphenyl-1,5-benzothiazepine 
• 60246-64-2 β-(2-Aminophenylmercapto)-β-phenyl-propiophenone 
• 1774-66-9 3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 156875-29-5 6-(4-bromo-phenyl)-2,3,4a-triphenyl-5,6-dihydro-4aH-4-oxa-7-thia-11b-aza-dibenzo[a,c]cyclohepten-1-one 

Relevant articles and documents

Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium

A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported. Here, glycerol, a biodegradable and reusable promoting medium, has been utilized under acid, base or metal-free conditions. The

Efficient and eco-friendly syntheses of 1,5-benzothiazepines and 1,5-benzodiazepines catalyzed by [Hmim][NO3] under mild conditions

This article presents a synthetic method and reaction mechanism of the 1,5-benzothiazepines and 1,5-benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven-membered rings) have also been determined and compared with thiazine (six-membered ring). In this method, N-methylimidazolium nitrate [Hmim][NO3] has been used as a catalyst that acts as an environmental friendly system.

2,4-DIARYL-2,3-DIHYDROBENZOTHIAZEPINES

2,4-Diaryl-2,3-dihydrobenzothiazepines are obtained in a single stage from chalcones and ortho-aminothiophenol in the presence of triethylamine.The nature of the electronic transitions in their UV absorption spectra is discussed with the use of quantum-chemical methods.It was shown that the seven-membered ring does not invert in the range of temperatures between -80 and +140 deg C and is in the boat form.The main initial event in the fragmentation of the molecules of the obtained compounds under electron impact is the formation of benzothiazole-containing radicalions.In an acidic medium 2,4-diphenyl-2,3-dihydrobenzothiazepine is hydrolyzed to 3-(2-aminophenylthio)-1,3-diphenyl-1-propanone, and in its reaction with 2,4-dinitrophenylhydrazine chalcone hydrazone and o-aminothiophenol are formed.