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5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER is a spiro compound derivative of spiro-indole-piperidine, characterized by the presence of a 5-fluoro substituent and a 1,1-dimethylethyl ester group, which is indicative of a tert-butyl group. This chemical compound is utilized in pharmaceutical research and may exhibit biological activities due to its distinctive structural features and functional groups, making it a candidate for potential applications in medicinal chemistry and drug discovery.

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  • 1'-BOC-5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]

    Cas No: 866028-06-0

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  • 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

    Cas No: 866028-06-0

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  • tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1H-spiro[indole-3,4-piperidine]-1-carboxylate

    Cas No: 866028-06-0

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  • 866028-06-0 Structure
  • Basic information

    1. Product Name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
    2. Synonyms: 1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate;tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate;tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat;5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate
    3. CAS NO:866028-06-0
    4. Molecular Formula: C17H21FN2O3
    5. Molecular Weight: 320.37
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 866028-06-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(866028-06-0)
    11. EPA Substance Registry System: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER(866028-06-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 866028-06-0(Hazardous Substances Data)

866028-06-0 Usage

Uses

Used in Pharmaceutical Research:
5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER is used as a research compound for exploring its potential biological activities and interactions with biological targets, which may contribute to the development of new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER is employed as a structural template for the design and synthesis of novel drug candidates, leveraging its unique features to target specific biological pathways or receptors.
Used in Drug Discovery:
5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER serves as a starting point in drug discovery processes, where its chemical properties and potential reactivity are assessed and optimized to create new pharmaceutical entities with desired therapeutic effects.
Note: Since the provided materials do not specify particular industries or reasons for the uses of 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER, the applications listed are general and based on the compound's potential in pharmaceutical and medicinal chemistry contexts.

Check Digit Verification of cas no

The CAS Registry Mumber 866028-06-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,0,2 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 866028-06:
(8*8)+(7*6)+(6*6)+(5*0)+(4*2)+(3*8)+(2*0)+(1*6)=180
180 % 10 = 0
So 866028-06-0 is a valid CAS Registry Number.

866028-06-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:866028-06-0 SDS

866028-06-0Downstream Products

866028-06-0Relevant articles and documents

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1 H-benzimidazol-2-ones as mGlu2 Receptor PAMs

De Lucas, Ana Isabel,Vega, Juan Antonio,Matesanz, Encarnación,Linares, María Lourdes,García Molina, Aránzazu,Tresadern, Gary,Lavreysen, Hilde,Trabanco, Andrés A.,Cid, José María

, p. 303 - 308 (2020)

Starting from two weak mGlu2 receptor positive allosteric modulator (PAM) HTS hits (4 and 5), a molecular hybridization strategy resulted in the identification of a novel spiro-oxindole piperidine series with improved activity and metabolic sta

RSV ANTIVIRAL COMPOUNDS

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Page/Page column 40, (2014/05/07)

Inhibitors of RSV replication of formula RI including stereochemically isomeric forms, and salts or solvates thereof, wherein R22, W, Q, V, Z p,s,and Het have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other RSV inhibitors, in RSV therapy.

ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST

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Page/Page column 60, (2010/02/14)

This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein Ri and R2 independently represent a hydrogen atom or the like; R3 represents a hydrogen atom, or the like; R4 represents a hydrogen atom or the like; (formula II) represents one of the following or the like; R5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxgen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

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