866050-58-0Relevant articles and documents
Synthesis and tranquillizing effect of new 1,4-benzoxazepines
Botros,Naguib,Osman
, p. 565 - 578 (2013/05/08)
A SERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4-benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the corresponding 1,4-benzoxazepine-5(4H)-thiones. N-alkylation of the 1,4-benzoxazepin-5(4H)-ones and S-alkylation of the 1,4-benzoxazepine-5(4H)-thiones were described. Some of the new compounds were subjected to preliminary screening for their tranquilizing effect.