866053-45-4Relevant academic research and scientific papers
Synthesis of new 2-aminobenzimidazole derivatives. Part 4*. Reactions of 2-arylideneaminobenzimidazole with selected β-ketoesters
Nawrocka,Kowalska,Sztuba,Drys,Wietrzyk,Filip
, p. 1753 - 1761 (2008/09/17)
Schiff bases 2-6 obtained from 2-aminobenzimidazole 1 with p-(N,N-diethylamino)-, p-chloro-, p-bromo-, 2,4-dimethoxy-, and 3,4-dimethoxybenzaldehyde were subjected to the reaction with 1,3-ketoester: methyl-, ethyl-, benzyl-, and t-butylacetoacetate to form derivatives of pyrimido[1,2-a]benzimidazole 7-23. 1H NMR spectra recorded for the compounds 20-23 in DMSO solution indicate the presence of two conformational forms. Compounds 2, 7-23 were examined for their antiproliferative activity in vitro against the cells of human lung cancer cell lines A549.
