866083-42-3

Basic information

• Product Name: (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile
• Synonyms: (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile
• CAS NO: 866083-42-3
• Molecular Formula: C6H8N2
• Molecular Weight: 108.14112
• Mol File: 866083-42-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 237℃
• Flash Point: 97℃
• Appearance: /
• Density: 1.15
• CAS DataBase Reference: (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile(866083-42-3)
• EPA Substance Registry System: (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carbonitrile(866083-42-3)

Safety Data

• Hazardous Substances Data: 866083-42-3(Hazardous Substances Data)

Usage

Uses

Saxagliptin hydrochloride monohydrate, an anti-diabetic drug can be synthesized using a coupling reaction of (S)-phthalimido-(3-hydroxy-adamantan-1-yl)acetic acid with (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-nitrile followed by removal of the phthalimide protecting group and treatment with HCl.

Upstream product

• 32431-85-9 2,5-dibromo-3-fluoro-thiophene 
• 361440-67-7 [1S-(1α,3β,5α)]-3-(aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid 1,1-dimethylethyl ester 
• 361442-57-1 (1S,3S,5S)-tert-butyl-3-cyano-2-azabicyclo[3.1.0]hexane-2-carboxylate 

Relevant articles and documents

STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF

The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound as shown in formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.

Preparation method for synthesizing 2-azabicyclo[4.1.0]heptane-1-carboxylic acid hydrochloride

The invention discloses a preparation method for synthesizing 2-azabicyclo[4.1.0]heptane-1-carboxylic acid hydrochloride. The preparation method comprises the following steps: firstly obtaining a compound III through electrophilic substitution by taking N-substituted-1,2,3,6-tetrahydropyridine (compound II) as a raw material; carrying out cycloaddition reaction of the compound III and a sulfur ylide reagent to obtain a compound IV; finally carrying out deamination protecting group and ester hydrolysis to obtain the 2-azabicyclo[4.1.0]heptane-1-carboxylic acid hydrochloride (compound I).