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4,4',4''-TRIS(BENZOYLOXY)TRITYL BROMIDE is a chemical compound utilized in organic synthesis as a protecting reagent for hydroxyl groups. It is characterized by its ability to protect and deprotect various functional groups in organic chemistry, particularly in the synthesis of complex molecules and pharmaceuticals. 4,4',4''-TRIS(BENZOYLOXY)TRITYL BROMIDE features a trityl group with three benzoyloxy groups attached, connected to a bromide ion, and appears as a white to off-white crystalline powder that is soluble in organic solvents like acetone and methylene chloride. Its versatility makes it a widely used reagent in the field of organic synthesis.
Used in Organic Synthesis:
4,4',4''-TRIS(BENZOYLOXY)TRITYL BROMIDE is used as a protecting reagent for hydroxyl groups during the synthesis of complex molecules and pharmaceuticals. It plays a crucial role in the protection and deprotection of functional groups, ensuring the successful synthesis of the desired compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4,4',4''-TRIS(BENZOYLOXY)TRITYL BROMIDE is used as a key reagent in the synthesis of various drugs. Its ability to protect and deprotect functional groups allows for the creation of complex molecular structures necessary for the development of new medications.
Used in Chemical Research:
4,4',4''-TRIS(BENZOYLOXY)TRITYL BROMIDE is also used in chemical research as a versatile reagent for studying the properties and reactions of various organic compounds. Its solubility in organic solvents and its ability to protect and deprotect functional groups make it an invaluable tool for researchers in the field of organic chemistry.

86610-66-4

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Check Digit Verification of cas no

The CAS Registry Mumber 86610-66-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,6,1 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 86610-66:
(7*8)+(6*6)+(5*6)+(4*1)+(3*0)+(2*6)+(1*6)=144
144 % 10 = 4
So 86610-66-4 is a valid CAS Registry Number.

86610-66-4 Well-known Company Product Price

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  • TCI America

  • (T1071)  4,4',4''-Tris(benzoyloxy)trityl Bromide [Hydroxyl Protecting Agent]  >97.0%(T)

  • 86610-66-4

  • 5g

  • 995.00CNY

  • Detail

  • TCI America

  • (T1071)  4,4',4''-Tris(benzoyloxy)trityl Bromide [Hydroxyl Protecting Agent]  >97.0%(T)

  • 86610-66-4

  • 25g

  • 3,460.00CNY

  • Detail

86610-66-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name [4-[bis(4-benzoyloxyphenyl)-bromomethyl]phenyl] benzoate

1.2 Other means of identification

Product number -
Other names Tris[4-(phenylcarbonyloxy)phenyl]methyl Bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86610-66-4 SDS

86610-66-4Relevant academic research and scientific papers

Modified 5'-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase

Ruda, Gian Filippo,Nguyen, Corinne,Ziemkowski, Przemyslaw,Felczak, Krzysztof,Kasinathan, Ganasan,Musso-Buendia, Alexander,Sund, Christian,Zhou, Xiao Xiong,Kaiser, Marcel,Ruiz-Perez, Luis M.,Brun, Reto,Kulikowski, Tadeusz,Johansson, Nils Gunnar,Gonzalez-Pacanowska, Dolores,Gilbert, Ian H.

experimental part, p. 309 - 320 (2012/01/12)

2'-Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this Plasmodium falciparum enzyme. Herein we report further structure-activity studies; in particular, variations of the 5'-trityl group, the introduction of various substituents at the 3'-position of deoxyuridine, and modifications of the base. Compounds were tested against both the enzyme and the parasite. Variations of the 5'-trityl group and of the 3'-substituent were well tolerated and yielded active compounds. However, there is a clear requirement for the uracil base for activity, because modifications of the uracil ring result in loss of enzyme inhibition and significant decreases in antiplasmodial action. Fewer trips to the dUMP: dUTPase is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this P.falciparum enzyme. Herein we report further structure-activity studies of the 5'-trityl group, the introduction of various substituents at the 3'-position of deoxyuridine, and modifications of the base.

4,4',4''-Tris(benzoyloxy)trityl as a New Type of Base-Labile Group for Protection of Primary Hydroxyl Groups

Sekine, Mitsuo,Hata, Tsujiaki

, p. 3011 - 3014 (2007/10/02)

4,4',4''-Tris(benzoyloxy)trityl bromide (TBTrBr) available from rosolic acid has proved to have several advantages as a primary-selective blocking agent for nucleoside hydroxyl groups over previously known hindered acylating agents.N-Protected deoxynucleo

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