866110-70-5Relevant academic research and scientific papers
Formation of the C3-C4 unsaturated framework of cribrostatin 4 via dead-mediated oxidation of an allylic tertiary amine
Vincent, Guillaume,Chen, Yuyin,Lane, Jonathan W.,Williams, Robert M.
, p. 385 - 398 (2008/03/12)
The formal synthesis of the tetrahydroisoquinoline alkaloid cribrostatin 4 (1) is described. The synthesis features as a key step a DEAD-mediated oxidation of an allylic tertiary amine to an iminium ion immediately followed by a Pictet-Spengler cyclizatio
