866122-72-7Relevant academic research and scientific papers
Dynamic covalent polypeptides showing tunable secondary structures and Thermoresponsiveness
Yan, Jiatao,Liu, Kun,Zhang, Xiuqiang,Li, Wen,Zhang, Afang
, p. 33 - 41 (2014)
Lysine-based polypeptides can be afforded with steerable secondary structures and tunable thermoresponsiveness through dynamic covalent OEGylation. These polypeptides were formed through dynamic imine linkage via reactions of amino moieties from poly(L-ly
Small-molecule AIEE (aggregation-induced emission enhancement) light emitting material with triple-stimulation responsiveness and method for preparing small-molecule AIEE light emitting material
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, (2018/10/19)
The invention discloses a small-molecule AIEE (aggregation-induced emission enhancement) light emitting material with triple-stimulation responsiveness and a method for preparing the small-molecule AIEE light emitting material. The small-molecule AIEE lig
Acid response water-soluble near-infrared BODIPY light-sensitive agent and preparation method thereof
-
, (2017/04/21)
The invention relates to an acid response water-soluble near-infrared BODIPY light-sensitive agent and a preparation method thereof. The novel BODIPY light-sensitive agent is soluble in water, has absorption performance in a near-infrared area, and has the advantages of being good in water solubility and high in light absorption in the near-infrared area. Meanwhile, the invention further provides the preparation method of the BODIPY light-sensitive agent. Synthesis is quick, and purification is easy. According to the preparation method, by reasonably designing feeding equivalence ratio, the target product can be obtained only through extraction, washing and other simple processing in triglycol monomethyl ether and p-toluenesulfonic acid sulfonylation; by means of the ethyl alcohol re-crystallization method, high-purity BODIPY is obtained; target molecules are synthesized at a high yield through reasonable temperature control. The method has the advantages of being easy to operate, convenient and safe to use and the like. The prepared light-sensitive agent can be soluble in water, the maximum absorption peak is 655 nm, the maximum emission peak is 710 nm, and the light emitting intensity of the light-sensitive agent is gradually improved along with addition of trifluoroacetic acid.
Self-Organization and Vesicle Formation of Amphiphilic Fulleromonodendrons Bearing Oligo(poly(ethylene oxide)) Chains
Chen, Mengjun,Zhu, Hongxia,Zhou, Shengju,Xu, Wenlong,Dong, Shuli,Li, Hongguang,Hao, Jingcheng
, p. 2338 - 2347 (2016/03/26)
A new series of N-methylfulleropyrrolidines bearing oligo(poly(ethylene oxide))-appended Percec monodendrons (fulleromonodendrons, 4a-f) have been synthesized. The substituted position of the oligo(poly(ethylene oxide)) chain(s) on the phenyl group of the Percec monodendron for 4a-f was varied, which is at the 4-, 2,4-, 3,5-, 3,4,5-, 2,3,4- and 2,4,6- position, respectively. 4a-e are obtained as solids at 25°C and can self-organize into lamellar phases as revealed by X-ray diffraction (XRD) and small-angle X-ray scattering (SAXS) measurements, while 4f appears as a viscous liquid. The substitution patterns of the oligo(poly(ethylene oxide)) chain(s) also significantly influence the solubility of 4a-f, especially in ethanol and water. Formation of self-organized supramolecular structures of 4d and 4e in water as well as 4d in ethanol is evidenced from UV-vis and dynamic light scattering (DLS) measurements. Further studies in water using various imaging techniques including transmission electron microscopy (TEM), freeze-fracture TEM (FF-TEM), cryo-TEM and atomic force microscopy (AFM) observations revealed the formation of well-defined vesicles for 4d and plate-like aggregates for 4e, indicating that the aggregation behavior of the fulleromonodendrons is highly dependent on their molecular structures. For 4d in ethanol, only irregular aggregates were noticed, indicating the solvent also plays a role on regulating the aggregation behavior. After functionalization with the Percec monodendrons, 4a-f can preserve the intriguing electrochemical properties of pristine C60 as revealed by cyclic voltammetries. The thermotropic properties of 4a-f have also been investigated. It was found that all of them show good thermal stability, but no mesophases were detected within the investigated temperature ranges. (Figure Presented).
Selective photosensitization through an and logic response: Optimization of the pH and glutathione response of activatable photosensitizers
Erbas-Cakmak, Sundus,Cakmak, Fatma Pir,Topel, Seda Demirel,Uyar, Taha Bilal,Akkaya, Engin U.
, p. 12258 - 12261 (2015/07/27)
A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.
Dynamic covalent polypeptides showing tunable secondary structures and thermoresponsiveness
Yan, Jiatao,Liu, Kun,Zhang, Xiuqiang,Li, Wen,Zhang, Afang
, p. 33 - 41 (2015/08/24)
Lysine-based polypeptides can be afforded with steerable secondary structures and tunable thermoresponsiveness through dynamic covalent OEGylation. These polypeptides were formed through dynamic imine linkage via reactions of amino moieties from poly(l-ly
A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: Hydrophobic-binding-driven bonding
Wolfe, Amanda L.,Duncan, Katharine K.,Lajiness, James P.,Zhu, Kaicheng,Duerfeldt, Adam S.,Boger, Dale L.
, p. 6845 - 6857 (2013/10/01)
Two systematic series of increasingly hydrophilic derivatives of duocarmycin SA that feature the incorporation of ethylene glycol units (n = 1-5) into the methoxy substituents of the trimethoxyindole subunit are described. These derivatives exhibit progressively increasing water solubility along with progressive decreases in cell growth inhibitory activity and DNA alkylation efficiency with the incremental ethylene glycol unit incorporations. Linear relationships of cLogP with -log IC50 for cell growth inhibition and -log AE (AE = cell-free DNA alkylation efficiency) were observed, with the cLogP values spanning the productive range of 2.5-0.49 and the -log IC50 values spanning the range of 11.2-6.4, representing IC50 values that vary by a factor of 105 (0.008 to 370 nM). The results quantify the fundamental role played by the hydrophobic character of the compound in the expression of the biological activity of members in this class (driving the intrinsically reversible DNA alkylation reaction) and define the stunning magnitude of its effect.
Real time self-assembly and reassembly of molecular nanowires of trigeminal amphiphile porphyrins
Xie, Yongshu,Akada, Misaho,Hill, Jonathan P.,Ji, Qingmin,Charvet, Richard,Ariga, Katsuhiko
supporting information; experimental part, p. 2285 - 2287 (2011/03/23)
Self-assembly and reassembly of high aspect ratio nanowires of trigeminal porphyrins and their manipulation using an atomic force microscope (AFM) is reported.
Synthesis and characterization of water-soluble phenylene-vinylene-based singlet oxygen sensitizers for two-photon excitation
Nielsen, Christian B.,Johnsen, Mette,Arnbjerg, Jacob,Pittelkow, Michael,McIlroy, Sean P.,Ogilby, Peter R.,Jorgensen, Mikkel
, p. 7065 - 7079 (2007/10/03)
The synthesis and characterization of water-soluble singlet oxygen sensitizers with a phenylene-vinylene motif is presented. The principal motivation for this study was to better understand specific features of a water-soluble molecule that influence the photosensitized production of singlet oxygen upon nonlinear, two-photon excitation of that molecule. To achieve water solubility, sensitizers were synthesized with ionic as well as nonionic substituents. In the ionic approach, salts of N-methylated pyridine, benzothiazole, and 1-methyl-piperazine moieties were used, as were aryl-substituted sulfonic acid moieties. In the nonionic approach, aryl-substituted triethylene glycol moieties were used. Selected photophysical properties of the compounds synthesized were determined, including singlet oxygen quantum yields. Of the molecules examined, the most efficient singlet oxygen sensitizers had triethylene glycol units as the functional group that imparted water solubility. Molecules containing the ionic moieties did not make singlet oxygen in appreciable yield nor did they efficiently fluoresce. Rather, for these latter molecules, rapid charge-transfer-mediated nonradiative processes appear to dominate excited state deactivation.
