866138-83-2

Upstream product

• 866138-77-4 (R)-4-benzyl-3-((R)-4-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)pentanoyl)oxazolidin-2-one 
• 590-86-3 isovaleraldehyde 
• 824-94-2 p-methoxybenzyl chloride 
• 86771-48-4 (4R)-4-[(4-methoxybenzyl)oxymethyl]-γ-butyrolactone 
• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 866138-76-3 (R)-4-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)pentanoic acid 

Downstream Products

• 866138-94-5 (2R,4S,5S)-2-tert-butyldimethylsilyloxy-5-methanesulfonyloxy-1-(4-methoxy)benzyloxy-7-methyl-4-(trityloxymethyl)octane 
• 866138-84-3 (2R,4S,5S)-2-tert-butyldimethylsilyloxy-5-hydroxy-1-(4-methoxy)benzyloxy-7-methyl-4-(trityloxymethyl)octane 
• 866138-93-4 (2R,4S,5S)-2-tert-butyldimethylsilyloxy-5-hydroxy-4-hydroxymethyl-1-(4-methoxy)benzyloxy-7-methyloctane 

Relevant academic research and scientific papers

Synthesis of (-)-amphidinolide K fragment C9-C22

(Chemical Equation Presented) The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (-)-amphidinolide K (1) has been achieved from synthons C9-C14 (3) and C15-C22 (4), which have both been prepared from glutamic acid in good overall yields.