866152-63-8Relevant academic research and scientific papers
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
Turan-Zitoun, Gülhan,Sa?lik, Begüm Nurpelin,?evik, Ulviye Acar,Levent, Serkan,Ilgin, Sinem,Hussein, Weiam
, p. 744 - 751 (2018)
A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a–2o) and their Schiff bases (3a–3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized compounds were confirmed by their IR, 1H-NMR, 13C-NMR spectroscopy and mass spectrometry. They were screened for their antimicrobial and antifungal activities. Additionally, in vitro cytotoxic acivity of the most active antifungal compound (3o) and ketoconazole was determined in NIH/3T3 cells by MTT assay. Compound 2i (4-{3-Amino-2-[(1-(furan-2-yl)ethylidene)hydrazono]-2,3-dihydrothiazol-4-yl}phenol) showed the greatest antifungal activity among the newly synthesized derivatives. Schiff bases (3c-3n) displayed an undeniable fungicidal action against Candida parapsilosis ATCC 22019 as intense as the reference ketoconazole. In addition, the most active Schiff base 3o (2-[(1-(Furan-2-yl)ethylidene)hydrazono]-N-(4-nitrobenzylidene)-4-(2,3,4-trichloro phenyl)thiazol-3(2H)-amine) showed the highest antifungal activity against both Candida krusei ATCC 6258 and Candida parapsilosis ATCC 22019, and was as potent as ketoconazole. Moreover, compound 3o was found to be non-cytotoxic against NIH/3T3 cells.
Synthesis of some thienyl-triazine derivatives and antimicrobial activity
Kaplancikli,Turan-Zitouni,Ozdemir,Altintop,Tunali
experimental part, p. 6701 - 6707 (2012/07/28)
Some 4-(1-aryl-ethylideneamino)-5-phenyl-1,4-dihydro-2H- [1,2,4]triazine-3-thione derivatives were synthesized and evaluated for their antimicrobial activity. The reaction of 2-acetylfuran or 2-acetylthiophene with thiocarbohydrazide yielded the N-(1-arylethylidene) thiocarbohydrazides which furnished the thienyl-triazine derivatives by reacting with phenacyl bromides. The chemical structures of the compounds were elucidated by IR, 1H NMR and FAB+-MS spectral data and elemental analyses. Microdilution broth susceptibility assay was used for the antimicrobial activity evaluation of the compounds against the strains Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia spp., Salmonella thyphimurium, Proteus vulgaris, Listeria monocytogenes, Candida glabrata, Candida albicans, Candida tropicalis. Chloramphenicol and ketoconazole were used as control drugs. A significant level of activity was observed.
