866227-25-0

Basic information

• Product Name: (2S,3S)-1-[(3-bromobenzyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol
• Synonyms: (2S,3S)-1-[(3-bromobenzyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol
• CAS NO: 866227-25-0
• Molecular Weight: 449.388
• Mol File: 866227-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-1-[(3-bromobenzyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-1-[(3-bromobenzyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol(866227-25-0)
• EPA Substance Registry System: (2S,3S)-1-[(3-bromobenzyl)amino]-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol(866227-25-0)

Safety Data

• Hazardous Substances Data: 866227-25-0(Hazardous Substances Data)

Upstream product

• 10269-01-9 3-bromobenzylamine 
• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 

Downstream Products

• 866227-49-8 Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(3-bromo-benzyl)-carbamoylmethyl-amino]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide 
• 866227-41-0 (5S,6S)-3-aza-3-(3-bromobenzyl)-6-{[(tert-butyloxycarbonyl)-L-valinyl]amino}-5-hydroxy-7-phenylheptanoyl amide 
• 866227-33-0 (5S,6S)-3-aza-3-(3-bromobenzyl)-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide 

Relevant articles and documents

Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II

The increasing resistance of the malarial parasite to antimalarial drugs is a major contributor to the reemergence of the disease and increases the need for new drug targets. The two aspartic proteases, plasmepsins I and II, from Plasmodium falciparum have recently emerged as potential targets. In an effort to inhibit these hemoglobinases, a series of inhibitors encompassing a basic hydroxyethylamine transition state isostere as a central fragment were prepared. The synthesized compounds were varied in the P1′ position and exhibited biological activities in the range of 31 to >2000 nM. To try to rationalize the results, molecular docking and 3D-QSAR analysis were used.