86625-33-4Relevant articles and documents
Synthesis of Heterocyclic Compounds, XXXVII Preparation of 4,6-Diaryl-1,2-dihydro-2-thioxo-3,5-pyridinedicarbonitriles and Related Compounds
Encinas, Maria Jesus Rubio,Seoane, Carlos,Soto, Jose L.
, p. 213 - 222 (2007/10/02)
The reaction of cyanothioacetamide (1) with α-benzoylcinnamonitriles 2 in basic ethanolic solution leads to 4,6-diaryl-1,2-dihydro-2-thioxo-3,5-pyridinedicarbonitriles 3 together with the disulfides 4.Treatment of 4 with 2-mercaptoethanol causes transformation into 3 which can lead to 4 upon reaction with either iodine-potassium iodide or dimethyl sulfoxide-trifluoroacetic acid.Methylation of 3 or 4 yields the expected methylthiopyridines 5.On the other hand, reaction of 3 with methyl chloroacetate allows the preparation of thienopyridines 8.