866252-00-8Relevant academic research and scientific papers
A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones
Betori, Rick C.,Miller, Eric R.,Scheidt, Karl A.
, p. 1131 - 1137 (2017)
A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in acc
1-AMINOSULFONYL-2-CARBOXYPYRROLE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS
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Page/Page column 68, (2021/05/29)
This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula
Tandem deprotection-dimerization-macrocyclization route to C2 symmetric cyclo-tetrapeptides
Ha, Khanh,Lebedyeva, Iryna,Hamedzadeh, Sadra,Li, Zhiliang,Quinones, Ryan,Pillai, Girinath G.,Williams, Byron,Nasajpour, Amir,Martin, Kristin,Asiri, Abdullah M.,Katritzky, Alan R.
supporting information, p. 4874 - 4879 (2014/05/06)
Dimerization-macrocyclization has been a long-standing problem in the cyclization of peptides since, together with the desired cyclic product, many cyclic oligomers and linear polymers may also be formed during the reaction. Therefore, the development of a process that affords the cyclic dimer predominantly is difficult. A novel and versatile strategy for the synthesis of symmetric cyclo-tetrapeptides by palladium-promoted tandem deprotection/cyclo- dimerization from readily available Cbz-dipeptidoyl benzotriazolides is reported (Cbz=carboxybenzyl).
Triphenylphosphoranylidene substituted heterocycles as versatile intermediates
Katritzky, Alan R.,Vincek, Adam S.,Steel, Peter J.
experimental part, p. 1401 - 1423 (2009/07/17)
N-Cbz-(α-aminoacyl)benzotriazoles 5a-e reacted with (stabilized-methylene)triphenylphosphoranes 6 and 13 to give the corresponding esters 7a-e (66-91%) or nitriles 14a-e (63-85%). Deprotection of N-Cbz-γ-amino-β-oxo-α-triphenylphosphoranylidene esters 7a-
