866319-00-8

Basic information

• Product Name: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE;5-FLUORO-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-;5-Fluoro-7-azaindole (5-Fluoro-1H-pyrrolo[2,3-b]pyridine);EOS-60587;5-Fluoro-1H-pyrrolo[2,3-b]pyridin
• CAS NO: 866319-00-8
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Product Categories: Heterocycles series;CHIRAL CHEMICALS;Fluorine series
• Mol File: 866319-00-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 112-113°C
• Appearance: /
• Density: 1.35
• Refractive Index: 1.658
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.04±0.40(Predicted)
• CAS DataBase Reference: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(866319-00-8)
• EPA Substance Registry System: 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(866319-00-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 866319-00-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H5FN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)

Upstream product

• 14618-78-1 4,4-dimethoxybutanenitrile 
• 823218-51-5 5-fluoro-3-iodo-pyridin-2-amine 
• 21717-96-4 2-amino-5-fluoropyridine 
• 866319-01-9 5-fluoro-3-(2-trimethylsilylethynyl)pyridine-2-amine 
• 869557-43-7 3-bromo-5-fluoropyridin-2-amine 
• 75-07-0 acetaldehyde 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 868387-37-5 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine 
• 936344-74-0 3-ethynyl-5-fluoro-pyridin-2-ylamine 

Downstream Products

• 1417421-99-8 3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1259279-57-6 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1015608-79-3 1-(benzenesulfonyl)-5-fluoropyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 
• 882033-66-1 4-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine 
• 1171920-17-4 5-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 868387-37-5 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine 
• 1259279-58-7 5-fluoro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)-pyrrolo[2,3-b]pyridine 
• 1259279-56-5 5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine 

Relevant articles and documents

ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE

The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF INFLUENZA VIRUS REPLICATION

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient a safe and effective amount of a compound represented by any of Formulas l-lll, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a safe and effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base