86632-65-7Relevant academic research and scientific papers
Synthesis of New Polyoxin Derivatives and Their Activity against Chitin Synthase from Candida albicans
Emmer, Gerhard,Ryder, Neil S.,Grassberger, Maximilian A.
, p. 278 - 281 (2007/10/02)
Two analogues of L-alanylpolyoxin C with a modified peptide bond were synthesized and tested for inhibition of chitin synthase in Candida albicans.N-Methylation of the peptide bond (compound 13) or the replacement of it by NH2CH2 (compound 9) led to loss
Design of anticandidal agents: Synthesis and biological properties of analogues of polyoxin L
Shenbagamurthi,Smith,Becker,Steinfeld,Naider
, p. 1518 - 1522 (2007/10/02)
Six analogues of polyoxin L were synthesized from uridine. All of these analogues inhibited chitin synthetase from Candida albicans. Derivatization of the amine terminus of the polyoxin analogues resulted in loss of activity, and analogues containing arom
