86636-03-5

Upstream product

• 86635-96-3 1-isopropyloxy-2,4-dimethoxybenzene 
• 121-33-5 vanillin 
• 13330-65-9 2,4-dimethoxyphenol 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 2538-98-9 4-isopropyloxy-3-methoxybenzaldehyde 

Downstream Products

• 146607-41-2 2-benzyloxy-5-isopropoxy-4-methoxybenzaldehyde 
• 139386-31-5 2-hydroxy-5-isopropoxy-4-methoxybenzaldehyde 
• 776-86-3 isoscopoletin 
• 68468-11-1 5-Formyl-6-hydroxy-7-methoxycoumarin 
• 86636-04-6 3,5-Dinitro-benzoic acid 4-isopropoxy-3-methoxy-phenyl ester 
• 146607-40-1 4-benzyloxy-1-isopropoxy-2-methoxybenzene 

Relevant academic research and scientific papers

IMIDAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF

The present invention relates to imidazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).

Synthetic studies on naturally occurring coumarins. II. Synthesis of 6,7-dimethoxy- and 7,8-dimethoxy-5-[(E)-3-oxo-1-butenyl]coumarins

In connection with studies on the structure elucidation of the so-called Reisch's coumarin isolated from Toddalia asiatica, syntheses of two coumarins (4 and 5) were accomplished via the routes shown in Charts 2 and 3, respectively. Melting points and NMR data of the synthesized coumarins (4 and 5) and of related coumarins (5-methoxysuberenon, toddalenone, and Reisch's coumarin) are given in Table I, suggesting that so-called Reisch's coumarin might be 4.

SELECTIVE DEALKYLATIONS OF ARYL ALKYL ETHERS AND THIOETHERS BY SODIUM IN HMPA

The reaction of sodium with bis- and tris(alkoxy)benzenes in HMPA gives selectively the products of monodealkylation.The reaction proceeds through a dianion which fragments into an alkyl and an aryloxy anion.The positional selectivity of this fragmentation is governed by the structure of both the alkyl and aryloxy groups.With bis- and tris(alkoxy)benzenes which for symmetry reasons can afford aryloxy anions having the same basicity, the dealkylation involves exlusively the less substituted alkyl group.On the contrary, in the asymmetric terms, the positional selectivity of the dealkylation process is governed by the basicity of the aryloxy anion.On the basis of these concepts several efficient and synthetically useful reactions have been developed.In most cases the selectivity obtained in the present reactions in different from that observed with other previously developed methods which use sodium methoxide or sodium alkenethiolates in HMPA.It is shown that the appropriate choice of the reagent allows selective dealkylation of the desired alkoxy group of a poly(alkoxy)benzene.The reaction of sodium with bis(alkylthio)benzenes in HMPA gives the bis(mercapto)benzenes.If the reduction is carried out with a solution of sodium in HMPA, the reaction gives instead the products of monodealkylation.This however is not selective.It is suggested that in the case of thioethers the dealkylation products originate from the fragmentation of the radical anions.