86636-92-2

Usage

Uses

Used in Chemical Research:
6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE is used as a fluorescent dye for its sensitivity and selectivity in detecting and analyzing biomolecules and other biological samples, contributing to the advancement of chemical research.
Used in Biochemical Studies:
In biochemical studies, 6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE is used as a fluorescent probe to facilitate the observation and analysis of biological processes, taking advantage of its high quantum yield and photostability.
Used in Materials Science:
6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE is utilized as a component in the development of new materials with fluorescent properties, enhancing their potential applications in various industries.
Overall, 6-ACRYLOYL-2-DIMETHYLAMINONAPHTHALENE is valued for its versatility and reliability in a wide range of analytical and research settings, making it an essential tool in scientific exploration and innovation.

InChI:InChI=1/C15H15NO/c1-4-15(17)13-6-5-12-10-14(16(2)3)8-7-11(12)9-13/h4-10H,1H2,2-3H3

Upstream product

• 15231-91-1 6-bromo-naphthalen-2-ol 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 50-00-0 formaldehyd 
• 5043-03-8 6?bromo?N,N?dimethylnaphthalen?2?amine 
• 911001-90-6 3-dimethylamino-1-(6-dimethylamino-naphthalen-2-yl)-propan-1-one 
• 305835-80-7 6-(methylamino)-2-bromonaphthalene 

Downstream Products

• 1429782-77-3 C₄₁H₅₅N₇O₁₀S 

Relevant academic research and scientific papers

Synthesis method of Acrylodan and analogues thereof

The invention belongs to the technical field of synthesis of fluorescent probes in biochemistry, and particularly relates to an environment-sensitive fluorescent probe and a synthesis process route of Acrylodan and analogues thereof. A method comprises the following steps: taking 6-methoxy-2-acetyl naphthalene as a raw material, carrying out substitution reaction on the 6-methoxy-2-acetyl naphthalene and a lithium amide salt, carrying out addition elimination reaction on an obtained amino-substituted acetyl naphthalene product and trifluoroacetic acid, and then carrying out addition elimination reaction on the obtained amino-substituted acetyl naphthalene product and aldehydes to finally obtain the high-purity Acrylodan compound and analogues. The method has the advantages of simple synthesis steps, short reaction time, high yield, low production cost and the like, and solves the problems of complex synthesis steps, harsh synthesis conditions and expensive synthesis raw materials in original synthesis methods. The optimization and improvement of the synthetic process route of Acrylodan and analogues can greatly promote the application of the environment-sensitive probe in the field of biochemistry.

A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding

The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan-derived fluorophore into the pharmacophore of an ATP-competitive kinase inhibitor. Fluorescence titration experiments demonstrate the solvatochromic properties of the inhibitor, in which dramatic increase in emission intensity and hypsochromic shift in emission maxima are clearly observed upon binding LCK. Microscopy experiments in cellular contexts together with flow cytometry show that the fluorescence intensity of the inhibitor correlates with the LCK concentration. Furthermore, multiphoton microscopy experiments demonstrate both the rapid cellular uptake of the inhibitor and that the two-photon cross section of the inhibitor is amenable for excitation at 700 nm.