866398-11-0

Basic information

• Product Name: (1R,3R,4R)-3-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-4-(3-hydroxypropyl)cyclohexanol
• Synonyms: (1R,3R,4R)-3-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-4-(3-hydroxypropyl)cyclohexanol
• CAS NO: 866398-11-0
• Molecular Weight: 390.607
• Mol File: 866398-11-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,3R,4R)-3-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-4-(3-hydroxypropyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R,4R)-3-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-4-(3-hydroxypropyl)cyclohexanol(866398-11-0)
• EPA Substance Registry System: (1R,3R,4R)-3-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-4-(3-hydroxypropyl)cyclohexanol(866398-11-0)

Safety Data

• Hazardous Substances Data: 866398-11-0(Hazardous Substances Data)

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 106591-04-2 1-(3-methoxyphenyl)heptan-1-ol 
• 100863-37-4 1-(3-methoxyphenyl)heptan-1-one 
• 111-25-1 1-bromo-hexane 
• 1374219-27-8 O-(1S,2S,4R)-4-hydroxy-2-[2-methoxy-4-(2-methyloctan-2-yl)phenyl]cyclohexyl S-methyl carbonodithioate 
• 24850-33-7 allyltributylstanane 
• 1374219-26-7 O-(1S,2S)-2-[2-methoxy-4-(2-methyloctan-2-yl)phenyl]-4-oxocyclohexyl S-methyl carbonodithioate 
• 1374219-25-6 O-(7S,8S)-7-[2-methoxy-4-(2-methyloctan-2-yl)phenyl]-1,4-dioxaspiro[4.5]decan-8-yl S-methyl carbonodithioate 
• 1374219-10-9 (7S,8S)-7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 1374219-11-0 C₂₄H₃₆O₄ 
• 1374219-24-5 7-(2-methoxy-4-(2-methyloctan-2-yl)phenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one 
• 1374219-14-3 7-iodo-1,4-dioxaspiro[4.5]dec-6-en-8-one 
• 1374219-15-4 2-methoxy-4-(2-methyloctan-2-yl)phenylboronic acid 
• 4683-24-3 1,4-dioxa-spiro[4.5]dec-6-en-8-one 

Downstream Products

• 83002-04-4 CP 55,940 

Relevant articles and documents

Enantioselective synthesis of (-)-CP-55940 via ruthenium-catalyzed asymmetric hydrogenation of ketones

A new and efficient catalytic asymmetric synthesis of the potent cannabinoid receptor agonist (-)-CP-55940 has been developed by using ruthenium-catalyzed asymmetric hydrogenation of racemic α-aryl ketones via dynamic kinetic resolution (DKR) as a key step. With RuCl2-SDPs/ diamine [SDPs=7,7'-bis(diarylphophino)-1,1'-spirobiindane] catalysts the asymmetric hydrogenation of racemic α-arylcyclohexanones via DKR provided the corresponding cis-β-arylcyclohexanols in high yields with up to 99.3% ee and >99:1 cis-selectivities. Both ethylene ketal group at the cyclohexane ring and ortho-methoxy group at the phenyl ring of the substrates 6 have little effect on the selectivity and reactivity of the hydrogenations. Based on this highly efficient asymmetric ketone hydrogenation, (-)-CP-55940 was synthesized in 13 steps (the longest linear steps) in 14.6% overall yield starting from commercially available 3-methoxybenzaldehyde and 1,4-cyclohexenedione monoethylene acetal. Copyright