866403-64-7Relevant academic research and scientific papers
4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors
Ishida, Junya,Hattori, Kouji,Yamamoto, Hirofumi,Iwashita, Akinori,Mihara, Kayoko,Matsuoka, Nobuya
, p. 4221 - 4225 (2007/10/03)
We have shown that a 4-phenyl-1,2,3,6-tetrahydropyridine fragment plays an important role in improving inhibitory potency against poly(ADP-ribose) polymerase-1 (PARP-1). Various benzamide analogues linked with this fragment via alkyl spacers have been prepared and evaluated. As a result, some of them have been found to be highly potent PARP-1 inhibitors.
