866454-66-2Relevant academic research and scientific papers
Chemoenzymatic synthesis of (protected) psymberlc acid
Pietruszka, Joerg,Simon, Robert Christian
, p. 3628 - 3634 (2009)
Two alternative approaches to the side-chain of psymberin (1), psymberic acid (5), have been developed starting from either racemic or enantiopure acetal 6. A five-step chemoenzymatic route provided the PMB-protected acid (S, S)-16 required for the coupli
Synthesis of psymberic acid
Henssen, Birgit,Kasparyan, Elena,Marten, Gernot,Pietruszka, Joerg
, p. 245 - 249 (2008/09/17)
A short synthesis of the unique side-chain of psymberin (1) - the psymberic acid (4) - is presented. Notable features of it include a highly selective aldol addition and an attempted enzymatic resolution step.
