866472-29-9

Usage

Class

Pyrazole amines

Potential Properties

Anti-cancer properties

Mechanism of Action

Inhibits the activity of certain enzymes involved in cancer cell growth and proliferation

Target Protein

JAK2

Involvement in Cancer

JAK2 is known to be involved in the development and progression of certain types of cancer

Current Status

Being further investigated for its therapeutic potential as a potential treatment for cancer

InChI:InChI=1/C11H12ClN3/c1-7-3-4-9(6-10(7)12)15-11(13)5-8(2)14-15/h3-6H,13H2,1-2H3

Upstream product

• 2469-99-0 Cyanoaceton 
• 51304-65-5 1-(3-chloro-4-methylphenyl)hydrazine 

Relevant academic research and scientific papers

Rhodium(II) Acetate-Catalysed Cyclization of Pyrazol-5-amine and 1,3-Diketone-2-diazo Compounds Using N,N-Dimethylformamide as a Carbon-Hydrogen Source: Access to Pyrazolo[3,4-b]pyridines

Access to pyrazolo[3,4-b]pyridines through a rhodium-catalysed intermolecular cyclization of pyrazol-5-amine and cyclic 1,3-diketone-2-diazo compounds, has been developed. A methyl carbon of N,N-dimethylformamide (DMF) performed as a carbon-hydrogen source for the construction of the pyridine ring. Various pyrazolo[3,4-b]pyridine derivatives were obtained under mild conditions using air as the terminal oxidant. (Figure presented.).