866475-55-0

Usage

Derivative of propane-1,3-diol

2-(4-bromobenzyl)propane-1,3-diol is derived from propane-1,3-diol, which is a basic organic compound with two hydroxyl (-OH) groups attached to the first and third carbon atoms.

4-bromobenzyl group attachment

In 2-(4-bromobenzyl)propane-1,3-diol, a 4-bromobenzyl group is attached to the second carbon atom, which modifies the properties and reactivity of the original propane-1,3-diol compound.

Building block in organic synthesis

2-(4-bromobenzyl)propane-1,3-diol is often used as a starting material or intermediate in the synthesis of more complex organic compounds, making it a valuable tool in organic chemistry.

Pharmaceutical research

The compound is also used in pharmaceutical research, as it can be a key component in the development of new drugs or drug candidates.

Potential biological activities

2-(4-bromobenzyl)propane-1,3-diol has been studied for its potential biological activities, such as antimicrobial and anti-inflammatory properties, which could lead to its use in medical applications.

Unique reactivity due to bromine atom

The presence of a bromine atom in the structure of 2-(4-bromobenzyl)propane-1,3-diol imparts unique reactivity and properties to the compound, making it a valuable tool for chemical and medicinal research.

Ongoing investigation

Further research is being conducted to explore the potential applications and effects of 2-(4-bromobenzyl)propane-1,3-diol, as its full range of properties and uses are not yet fully understood.

Upstream product

• 70146-78-0 diethyl 2-(4-bromobenzyl)malonate 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 866475-56-1 3-(4-bromophenyl)-2-(tert-butyldimethylsilanyloxymethyl)propan-1-ol 
• 1024021-65-5 C₁₃H₁₇BrO₂ 
• 902143-21-9 [4-(2-{4-[2-(4-bromobenzyl)-3-(tert-butyldimethylsilanyloxy)propoxy]phenyl}vinyl)phenyl]dimethylamine 
• 866475-57-2 [2-bromomethyl-3-(4-bromophenyl)propoxy]-tert-butyldimethylsilane 

Relevant academic research and scientific papers

Photoredox/Nickel Dual Catalysis Enables the Synthesis of Alkyl Cyclopropanes via C(sp3)-C(sp3) Cross Electrophile Coupling of Unactivated Alkyl Electrophiles

A facile synthesis of mono-, 1,1- and 1,2-disubstituted cyclopropanes via visible light-mediated photoredox/nickel dual catalysis is demonstrated. The challenging intramolecular C(sp3)-C(sp3) cross-electrophile coupling of readily available unactivated 1,3-dialkyl electrophiles was performed under mild conditions that allowed traditionally reactive functional groups to be included. Mechanistic inspection and control experiments revealed the importance of dual catalysis and that the reaction proceeds via a stepwise oxidative addition followed by an intramolecular SN2 reaction.

Biocatalytic Desymmetrization of Prochiral 3-Aryl and 3-Arylmethyl Glutaramides: Different Remote Substituent Effect on Catalytic Efficiency and Enantioselectivity

Catalyzed by an amidase-containing Rhodococcus erythropolis AJ270 microbial whole cell catalyst in neutral phosphate buffer at 30 °C, desymmetric hydrolysis of a series of prochiral 3-aryl and 3-arylmethylglutaramides efficiently afforded 3-substituted glutaric acid monoamides in up to 95% yield and >99.5% ee. Even far away from the reaction site, the substituents on the aryl still have a significant effect on the catalytic activity and enantioselectivity and different remote substituent effect was observed for the two types of substrates. The synthetic application of biocatalytic desymmetrization was demonstrated by the facile transformation of the obtained enantiopure (R)-3-substituted 4-carbamoylbutanoic acid products to chiral dihydroquinolinone and δ-lactone compounds. (Figure presented.).

ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF

Disclosed are an aryl glycoside compound as represented by formula I or formular I′, a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.

ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF

Disclosed are an aryl glycoside compound as represented by formula I or formular I', a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof. The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.

Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

A new series of 1,3-dioxane-2-carboxylic acid derivatives was synthesized and evaluated for agonist activity at human peroxisome proliferator-activated receptor (PPAR) subtypes. Structure-activity relationship studies led to the identification of 2-methyl-c-5-[4-(5-methyl-2-phenyl-1,3-oxazol-4-yl)butyl]-1,3-dioxane-r-2-carboxylic acid 4b as a potent PPARα agonist with high subtype selectivity at human receptor subtypes. This compound exhibited a substantial hypolipidemic effect in type 2 diabetic KK-Ay mice.

F-18 stilbenes as PET imaging agents for detecting β-amyloid plaques in the brain

Imaging agents targeting β-amyloid (Aβ) may be useful for diagnosis and treatment of patients with Alzheimer's disease (AD). Compounds 3e and 4e are fluorinated stilbene derivatives displaying high binding affinities for Aβ plaques in AD brain homogenates (Ki = 15 ± 6 and 5.0 ± 1.2 nM, respectively). In vivo biodistributions of [ 18F]Se and [18F]4e in normal mice exhibited excellent brain penetrations (5.55 and 9.75% dose/g at 2 min), and rapid brain washouts were observed, especially for [18F]4e (0.72% dose/g at 60 min). They also showed in vivo plaque labeling in APP/PS1 or Tg2576 transgenic mice, animal models for AD. Autoradiography of postmortem AD brain sections and AD homogenate binding studies confirmed the selective and specific binding properties to Aβ plaques. In conclusion, the preliminary results strongly suggest that these fluorinated stilbene derivatives, [18F]3e and [18F]4e, are suitable candidates as Aβ plaque imaging agents for studying patients with AD.