866540-38-7

Upstream product

• 15996-83-5 1-[4-(trifluoromethyl)phenyl]ethanone oxime 
• 1079-66-9 chloro-diphenylphosphine 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 

Downstream Products

• 1309465-13-1 (4S,5R)-methyl 1-(diphenylphosphinoyl)-4,5-dimethyl-2-thioxo-5-(4-(trifluoromethyl)phenyl)imidazolidine-4-carboxylate 

Relevant academic research and scientific papers

Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines

Here we report highly efficient and chemoselective azadiene-imine reductive couplings catalyzed by (Ph-BPE)Cu-H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereom

Synthesis of Air- and Moisture-Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction

Air-/moisture-stable, crystalline, and storable chiral salicyloxazoline based oxorhenium(V) complexes have been synthesized and their catalytic application for the asymmetric reduction of ketimines using hydrosilane as hydride source is disclosed. A broad substrate scope, high yields, and excellent enantioselectivities (up to 99 %) are attained. Furthermore, the syntheses of enantiopure α-amino esters, γ- and δ-lactams, and isoindolinones have also been carried out using this methodology. Finally, the method has been applied to synthetic targets of pharmaceutical relevance, such as R-(+)-salsolidine and R-(+)-crispine A.

Enantioselective reduction of ketones and imines catalyzed by (CN-Box)ReV-oxo complexes

The development and application of chiral, non-racemic ReV-oxo complexes to the enantioselective reduction of prochiral ketones is described. In addition to the enantioselective reduction of prochiral ketones, we report the application of these complexes to 1) a tandem Meyer-Schuster rearrangement/reduction to access enantioenriched allylic alcohols and 2) the enantioselective reduction of imines.