866555-07-9Relevant academic research and scientific papers
Total synthesis and biological evaluation of halipeptins A and D and analogues
Nicolaou,Lizos, Dimitrios E.,Kim, David W.,Schlawe, Daniel,De Noronha, Rita G.,Longbottom, Deborah A.,Rodriquez, Manuela,Bucci, Mariarosaria,Cirino, Giuseppe
, p. 4460 - 4470 (2007/10/03)
The marine-derived halipeptins A (1a) and D (1d) and their analogues 3a, 3d and 4a, 4d were synthesized starting from building blocks 10, 13, 14a or 14d, 15, and 16. The first strategy for assembling the building blocks, involving a macrolactamization rea
Total synthesis of halipeptins A and D and analogues
Nicolaou,Kim, David W.,Schlawe, Daniel,Lizos, Dimitrios E.,De Noronha, Rita G.,Longbottom, Deborah A.
, p. 4925 - 4929 (2007/10/03)
(Chemical Equation Presented) Deceptive rings: Halipeptins A (1 a) and D (1 b) and analogues thereof were synthesized from fragments 2 and 3 a, b, respectively. Key steps included peptide-bond formation, DAST-induced thiazoline construction, and macrolact
