866560-18-1Relevant academic research and scientific papers
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis
Oppong, Kofi A.,Ellis, Christopher D.,Laufersweiler, Michael C.,O'Neil, Steven V.,Wang, Yili,Soper, David L.,Baize, Mark W.,Wos, John A.,De, Biswanath,Bosch, Gregory K.,Fancher, Amy N.,Lu, Wei,Suchanek, Maureen K.,Wang, Richard L.,Demuth Jr., Thomas P.
, p. 4291 - 4294 (2005)
A novel diazocan containing dipeptide mimetic was synthesized via reductive N-N bond cleavage of a pyrazolidino-pyrazolidine using Raney-Ni and evaluated as an ICE inhibitor. This versatile 8-membered ring containing scaffold possesses an N-5 ring nitroge
