86658-78-8Relevant articles and documents
Construction of the Pyrrolo[2,3- d]carbazole Core of Spiroindoline Alkaloids by Gold-Catalyzed Cascade Cyclization of Ynamide
Matsuoka, Junpei,Kumagai, Hiroshi,Inuki, Shinsuke,Oishi, Shinya,Ohno, Hiroaki
, p. 9358 - 9363 (2019)
We achieved direct construction of the common pyrrolo[2,3-d]carbazole core of aspidosperma and malagasy alkaloids by a gold-catalyzed cascade cyclization of ynamide. This reaction involves intramolecular cyclization from indole to ynamide followed by trapping of the resulting iminium intermediate. Through the use of chiral gold complexes, an enantiomerically enriched pyrrolo[2,3-d]carbazole was obtained in up to 74% ee. This methodology was successfully applied to the asymmetric formal synthesis of vindorosine.
Rhodium-Catalyzed Stereoselective Cyclization of 3-Allenylindoles and N-Allenyltryptamines to Functionalized Vinylic Spiroindolenines
Becker, Antonia,Breit, Bernhard,Grugel, Christian P.
supporting information, p. 3788 - 3792 (2021/05/29)
Herein, we report a highly enantio- and diastereoselective rhodium-catalyzed cyclization of N-allenyltryptamines and 3-allenylindoles to 6-membered spirocyclic indolenines. This allylic addition methodology offers the advantage of using a comparably cheap commercially available ligand with low loadings of an affordable rhodium precursor. The products can be converted into functionalized spirooxindoles and spiroindolines, which are regarded as important building blocks for the synthesis of a lot of natural products with biological activities.
Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats
Taha, Muhammad,Imran, Syahrul,Salahuddin, Mohammed,Iqbal, Naveed,Rahim, Fazal,Uddin, Nizam,Shehzad, Adeeb,Khalid Farooq, Rai,Alomari, Munther,Mohammed Khan, Khalid
, (2021/03/26)
We have synthesized new hybrid class of indole bearing sulfonamide scaffolds (1–17) as α-glucosidase inhibitors. All scaffolds were found to be active except scaffold 17 and exhibited IC50 values ranging from 1.60 to 51.20 μM in comparison with