866599-87-3

Basic information

• Product Name: {3-[(E)-2-(benzyl-phenyl-carbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid
• CAS NO: 866599-87-3
• Molecular Weight: 435.482
• Mol File: 866599-87-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {3-[(E)-2-(benzyl-phenyl-carbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[(E)-2-(benzyl-phenyl-carbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid(866599-87-3)
• EPA Substance Registry System: {3-[(E)-2-(benzyl-phenyl-carbamoyl)-2-cyano-vinyl]-indol-1-yl}-acetic acid(866599-87-3)

Safety Data

• Hazardous Substances Data: 866599-87-3(Hazardous Substances Data)

Upstream product

• 1422433-11-1 C₂₉H₂₅N₃O₃ 
• 1428648-25-2 C₁₆H₁₃ClN₂O₃ 
• 1428648-00-3 C₁₆H₁₄N₂O₄ 
• 1422432-77-6 C₂₀H₂₂N₂O₄ 
• 75629-56-0 C₁₇H₂₁N₂O₂⁽¹⁺⁾*Br^(1-) 
• 75629-45-7 (Z)-3-(pyrrolidin-1-ylmethylene)-3H-indole 
• 487-89-8 Indole-3-carboxaldehyde 

Relevant articles and documents

Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold

(E)-2-(3-(3-((3-Bromophenyl)amino)-2-cyano-3-oxoprop-1-en-1-yl) -1H-indol-1-yl)acetic acid (1) was discovered in a HTS campaign for CRTh2 receptor antagonists. An SAR around this hit could be established and representatives with interesting activity profiles were obtained. Ring closing tactics to convert this hit series into a novel 2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indole based CRTh2 receptor antagonist series is presented.