866615-27-2

Upstream product

• 81879-64-3 3-benzyl-3-azabicyclo[3.3.1]nonan-9-one 
• 108-94-1 cyclohexanone 
• 100-46-9 benzylamine 
• 55686-29-8 N,N-bis(ethoxymethyl)benzylamine 
• 104247-86-1 N-benzyl-1-methoxy-N-(methoxymethyl)methanamine 

Downstream Products

• 866778-18-9 9-[2-methoxymethoxy-4-(trifluoromethyl)phenoxy]-3-benzyl-3-azabicyclo[3.3.1]nonane 
• 866615-28-3 9-[2-methoxymethoxy-4-(trifluoromethyl)phenoxy]-3-benzyl-3-azabicyclo[3.3.1]nonane 
• 90483-13-9 3-azabicyclo[3.3.1]nonan-9-ol 

Relevant academic research and scientific papers

Preparation method of levo-demethyl benzene ring nonyl ester hydrochloride

The invention belongs to the technical field of medicine preparation, and discloses a preparation method of levo-demethylated benzene ring nonyl ester hydrochloride, the molecular formula of the levo-demethylated benzene ring nonyl ester hydrochloride is shown as (1), the method comprises the following steps: (1) preparing (R)-alpha-phenyl-alpha-cyclopentyl-alpha-methyl glycolate; (2) preparing anintermediate, wherein the intermediate is N-benzyl-3-azabicyclo-[3.3. 1]-non-9 [alpha]-alcohol; and (3) carrying out transesterification on the (R)-alpha-phenyl-alpha-cyclopentyl-alpha-methyl glycolate and N-benzyl-3-azabicyclo-[3.3. 1]-non-9 alpha-ol, removing benzyl on N through catalytic hydrogenation to obtain a crude product of L-demethyl benzene ring nonyl ester, salifying, and recrystallizing to obtain the L-hydrochloric acid demethyl benzene ring nonyl ester. The method is environmentally friendly and suitable for large-scale production.

Preparation method of demethyl levophencynonate hydrochloride

The invention belongs to the field of preparation of chemical intermediates, and specifically relates to a preparation method of demethyl levophencynonate hydrochloride. The preparation method is characterized in that benzylamine as a raw material is prepared into N,N-diethoxy methyl benzylamine; the N,N-diethoxy methyl benzylamine reacts with cyclohexanone and is selectively reduced, and reacts with (R)-alpha-phenyl-alpha-cyclopentyl-alpha-methyl glycolate; and a target product, namely the demethyl levophencynonate hydrochloride, is obtained through hydrogenation and salifying. The yield is improved; the cost is reduced; and operation is simple.

FXR RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR, AND USES THEREOF

The present disclosure disclosed a modulator of FXR receptor and preparation and use thereof, which relates to the technical filed of medicinal chemistry. The present disclosure provides a modulator of FXR receptor having a structural formula I or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, which can combine with FXR receptor (that is NR1H4) and be acted as a FXR agonist or a partial agonist for preventing and treating the disease mediated by FXR, such as chronic intrahepatic or extrahepatic cholestasis, hepatic fibrosis caused by chronic cholestasis or acute intrahepatic cholestasis, chronic hepatitis B, gallstone, hepatic carcinoma, colon cancer or intestinal inflammatory disease, etc. Specifically, for some chemical compounds, their EC50 for FXR agonist activity reach below 100nM, which show an excellent FXR agonist activity and an excellent prospect to provide a new pharmaceutical selection in clinical treatment for the disease mediated by FXR.

CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT

A chemical compound represented by the formula [I]: (wherein R 1 represents a hydroxyl group or the like, m represents 0 or an integer of 1 to 5, R 2 represents a halogen atom or the like, k represents 0 or an integer of 1 to 4, R 3 , R 31 , R 4 , R 41 ,