866633-25-2

Usage

Uses

Used in Pharmaceutical Industry:
2-bromo-4-fluoro-1-(trifluoromethoxy)benzene is used as a key intermediate in the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new medications with specific therapeutic properties, contributing to advancements in healthcare and medicine.
Used in Agrochemical Industry:
In the agrochemical sector, 2-bromo-4-fluoro-1-(trifluoromethoxy)benzene is utilized as a building block for the creation of new agrochemicals. Its incorporation into these products can enhance crop protection and yield, supporting agricultural productivity and food security.
Used in Organic Synthesis:
2-bromo-4-fluoro-1-(trifluoromethoxy)benzene is employed as a versatile building block in organic synthesis. Its reactivity and structural features make it suitable for the construction of complex organic molecules, facilitating the development of novel compounds with diverse applications.
Used in Polymer Production:
2-bromo-4-fluoro-1-(trifluoromethoxy)benzene is also used in the production of polymers and other materials. Its properties enable the creation of polymers with specific characteristics, such as enhanced stability, reactivity, or functionality, which can be applied in various industries, including plastics, coatings, and adhesives.
Used in Research and Development:
2-bromo-4-fluoro-1-(trifluoromethoxy)benzene plays a significant role in research and development within the field of organic chemistry. It is used as a model compound to study reaction mechanisms, explore new synthetic routes, and develop innovative methodologies, thereby advancing the understanding and capabilities of chemical science.

Upstream product

• 191602-54-7 3-bromo-4-(trifluoromethoxy)aniline 
• 1032723-98-0 5-fluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1035797-66-0 benzoic acid trifluoromethyl ester 
• 618-32-6 Benzoyl bromide 
• 866633-24-1 C₁₃H₈BrFOS₂ 

Downstream Products

• 866633-26-3 [2-(trifluoromethoxy)-5-fluorophenyl]boronic acid 
• 1076245-71-0 N-{6-amino-5-[5-fluoro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-1-methyl-1H-pyrazole-5-carboxamide 
• 1076245-69-6 N-{6-amino-5-[5-fluoro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-3-methylisoxazole-4-carboxamide 

Relevant academic research and scientific papers

Perfluoro alkoxylation reagent and preparation method and application thereof

The invention provides a perfluoro alkoxylation reagent and a preparation method and application thereof. Specifically, the provided perfluoro alkoxylation reagent shown as a formula A can be used fornormal perfluoro alkoxylation reactions in the field, especially trifluoromethylation. Raw materials related to the perfluoro alkoxylation reagent are low in price and easy to obtain, the reaction condition is mild, the operation is simple, the cost is low, and the reagent is easy to popularize and suitable for large-scale production. The formula A is as shown in the description.

Trifluoromethyl Benzoate: A Versatile Trifluoromethoxylation Reagent

Trifluoromethyl benzoate (TFBz) is developed as a new shelf-stable trifluoromethoxylation reagent, which can be easily prepared from inexpensive starting materials using KF as the only fluorine source. The synthetic potency of TFBz is demonstrated by trifluoromethoxylation-halogenation of arynes, nucleophilic substitution of alkyl (pseudo)halides, cross-coupling with aryl stannanes, and asymmetric difunctionalization of alkenes. The unprecedented trifluoromethoxylation-halogenation of arynes proceeds smoothly at room temperature with the aid of a crown ether-complexed potassium cation, which significantly stabilizes the trifluoromethoxide anion derived from TFBz.

O-Trifluoromethylation of Phenols: Access to Aryl Trifluoromethyl Ethers by O-Carboxydifluoromethylation and Decarboxylative Fluorination

A new strategy for the synthesis of aryl trifluoromethyl ethers (ArOCF3) by combining O-carboxydifluoromethylation of phenols and subsequent decarboxylative fluorination is reported. This protocol allows easy construction of functionalized trifluoromethoxybenzenes and trifluoromethylthiolated arenes (ArSCF3) in moderate to good yields. Moreover, it utilizes accessible and inexpensive reagents sodium bromodifluoroacetate and SelectFluor II and, thus, is practical for O-trifluoromethylation of phenols. The potential application of this method is demonstrated with the preparation of a plant-growth regulator, Flurprimidol.

N- [6-AMINO-S- (PHENYL) PYRAZIN-2-YL] -ISOXAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NAV1.8 CHANNEL MODULATORS FOR THE TREATMENT OF PAIN

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.

PYRIDINE DERIVATIVES

The present invention relates to compounds of the formula (I): (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.

BIARYL SUBSTITUTED PYRAZINONES AS SODIUM CHANNEL BLOCKERS

Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other thera