866648-49-9

Upstream product

• 100-46-9 benzylamine 
• 87976-86-1 4‐aminocyclohexanone 
• 866648-50-2 (cis-4-benzylamino-cyclohexyl)-carbamic acid tert-butyl ester 

Downstream Products

• 881891-33-4 cis-N-benzyl-N'-(4-chloro-6-methyl-1-oxidopyridin-2-yl)cyclohexane-1,4-diamine 
• 881891-52-7 cis-N-benzyl-N'-(4-chloro-1-oxidopyridin-2-yl)cyclohexane-1,4-diamine 
• 881890-96-6 cis-N-benzyl-N'-(4-chloro-5-methyl-1-oxidopyridin-2-yl)cyclohexane-1,4-diamine 
• 881891-58-3 cis-N-benzyl-N'-(6-bromo-1-oxidopyridin-2-yl)cyclohexane-1,4-diamine 

Relevant academic research and scientific papers

A rapid and practical entry into cis-1,4-aminocyclohexanols

A selective and practical approach for the formation of cis-1,4-aminocyclohexanol was developed. The key transformation involves a one-pot imine formation/ Lewis acid-directed imine reduction and results in a highly selective attack of the reducing agent. This simple and practical method is easily amenable to large-scale synthesis.

PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR

The present invention encompasses novel substituted pyridine compounds of Formula (I), which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF

The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson’s disease, epilepsy, and addiction.