86678-91-3Relevant articles and documents
All Non-Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis
Opie, Christopher R.,Noda, Hidetoshi,Shibasaki, Masakatsu,Kumagai, Naoya
, p. 4648 - 4653 (2019)
The B3NO2 six-membered heterocycle (1,3-dioxa-5-aza-2,4,6-triborinane=DATB), comprising three different non-carbon period 2 elements, has been recently demonstrated to be a powerful catalyst for dehydrative condensation of carboxylic acids and amines. The tedious synthesis of DATB, however, has significantly diminished its utility as a catalyst, and thus the inherent chemical properties of the ring system have remained virtually unexplored. Here, a general and facile synthetic strategy that harnesses a pyrimidine-containing scaffold for the reliable installation of boron atoms is disclosed, giving rise to a series of Pym-DATBs from inexpensive materials in a modular fashion. The identification of a soluble Pym-DATB derivative allowed for the investigation of the dynamic nature of the B3NO2 ring system, revealing differential ring-closing and -opening behaviors depending on the medium. Readily accessible Pym-DATBs proved their utility as efficient catalysts for dehydrative amidation with broad substrate scope and functional-group tolerance, offering a general and practical catalytic alternative to reagent-driven amidation.
Antimicrobial activity of cholane compounds. Cholic and deoxycholic acids derivatives (Part 1)
Bellini,Quaglio,Guarneri,Cavazzini
, p. 185 - 190 (2007/10/02)
A series of compounds of (3 α, 5 β, 7 α, 12 α) 3, 7, 12-trihydroxy and (3 α, 5 β, 12 α) 3, 12-dihydroxy-cholanic acids was synthesized and their in vitro antibacterial activity was determined against a variety of Gram-negative and Gram-positive strains. Some of the compounds show an interesting antimicrobial activity against Gram-positive strains.
