866782-59-4

Usage

Uses

Used in Organic Synthesis:
8-Fluoro-3-iodoquinoline is used as a synthetic building block for creating new chemical compounds with diverse properties. Its presence in the molecular structure allows for the development of compounds with enhanced reactivity and stability.
Used in Pharmaceutical Research:
8-Fluoro-3-iodoquinoline is utilized as a pharmaceutical intermediate, contributing to the discovery and development of new drug molecules. Its unique structure and properties make it a promising candidate for the synthesis of potential therapeutic agents.
Used in Drug Discovery:
8-Fluoro-3-iodoquinoline is employed as a valuable compound in the field of drug discovery, where its versatile reactivity and properties can be harnessed to create novel drug candidates with potential therapeutic applications.

InChI:InChI=1/C9H5FIN/c10-8-3-1-2-6-4-7(11)5-12-9(6)8/h1-5H

Upstream product

• 394-68-3 8-fluoroquinoline 

Downstream Products

• 933792-11-1 3-[(4-chlorophenyl)sulfonyl]-8-fluoroquinoline 
• 866782-60-7 8-fluoro-3-(phenylsulfonyl)quinoline 
• 933824-72-7 3-(phenylsulfonyl)-N-[2-(4-pyridinyl)ethyl]-8-quinolinamine 
• 933792-04-2 3-[(4-chlorophenyl)sulfonyl]-N-(tetrahydro-2H-pyran-4-ylmethyl)-8-quinolinamine 
• 1066836-04-1 N-(tetrahydro-2H-pyran-4-ylmethyl)-3-({4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-8-quinolinamine 

Relevant academic research and scientific papers

Method for preparing 8-fluoroquinoline and method for preparing 3-iodo-8-fluoroquinoline

The invention provides a method for preparing 8-fluoroquinoline and a method for preparing 3-iodo-8-fluoroquinoline. Preparation of the 8-fluoroquinoline comprises the step of carrying out a ring-closure reaction between fluoroaniline and glycerin, and preparation of the 3-iodo-8-fluoroquinoline comprises the step of carrying out a substitution reaction among the prepared 8-fluoroquinoline, N-chlorosuccinimide and a metal iodide. The method has the characteristics that the raw materials are cheap and readily available, the cost is low, any special equipment is not needed, the various materialsare low in toxicity, safe, environmental-friendly, less in by-products and high in yield, and large-scale industrial production is easily realized.

COMBINATION OF CB2 LIGAND AND PARACETAMOL

Combination of one or more CB2 modulators and paracetamol are useful of treating conditions which are mediated by the activity of CB2 receptors such as an immune disorder, an inflammatory disorder, pain, rheumatoid arthritis, multiple sclerosis, osteoarthritis, and osteoporosis.

NOVEL QUINOLINE COMPOUNDS CAPABLE OF BINDING AT THE CB2 RECEPTOR

The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which possess are capable of selectively modulating the cannabinoid 2 receptor and the use of such compounds or pharmaceutical compositions thereof in the tr

NOVEL CHEMICAL PROCESS FOR THE SYNTHESIS OF QUINOLINE COMPOUNDS

A novel, simplified and economic process is described for making 3-phenylsulphonyl quinolines with an amine group at position 8 of the quinoline ring system, including 3-phenylsulfonyl-8-piperazin-1-yl-quinoline in particular, in the absence of a palladiu

3-((HETERO)ARYLSULFONYL)-8-` (AMINOALKYL)OXY!QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS

The present invention relates to novel quinoline derivatives such as compounds of the formula (I): and the use of such compounds or pharmaceutical compositions thereof in the treatment of CNS and other disorders.

3-ARYLSULFONYL-QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS

The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which have antagonist potency for the 5-HT6 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of C