866836-97-7

Basic information

• Product Name: 2',3',5'-tri-O-acetyl-5-(2-bromoethynyl)uridine
• Synonyms: 2',3',5'-tri-O-acetyl-5-(2-bromoethynyl)uridine
• CAS NO: 866836-97-7
• Molecular Weight: 473.234
• Mol File: 866836-97-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2',3',5'-tri-O-acetyl-5-(2-bromoethynyl)uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3',5'-tri-O-acetyl-5-(2-bromoethynyl)uridine(866836-97-7)
• EPA Substance Registry System: 2',3',5'-tri-O-acetyl-5-(2-bromoethynyl)uridine(866836-97-7)

Safety Data

• Hazardous Substances Data: 866836-97-7(Hazardous Substances Data)

Upstream product

• 84500-33-4 2',3',5'-tri-O-acetyl-5-iodouridine 

Relevant articles and documents

Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity

In this article, we report the synthesis of hitherto unknown 5-haloethynyl and 5-(1,2-dihalo)vinyluracil nucleosides in the 2′-deoxy, 3′-deoxy- and ribosyl series, and we discuss their in vitro anti-HIV and anti-HCV activities and cellular toxicitites. As a result, on the basis of their selectivity index (SI) obtained with the HCV replicon system, but also on their cytotoxicity on peripheral blood mononuclear, CEM and VERO cell lines, the best compounds were the 5-bromoethynyluridine (SI = 3.2) and the 5-(1-chloro-2-iodo) vinyluridine (SI > 2.8).