86684-07-3

Basic information

• Product Name: 3-Phenyl-isoxazol-5-yl-(3-piperidin-1-yl-propyl)-amine
• Synonyms: 3-Phenyl-isoxazol-5-yl-(3-piperidin-1-yl-propyl)-amine
• CAS NO: 86684-07-3
• Molecular Weight: 285.389
• Mol File: 86684-07-3.mol

Chemical Properties

• CAS DataBase Reference: 3-Phenyl-isoxazol-5-yl-(3-piperidin-1-yl-propyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-isoxazol-5-yl-(3-piperidin-1-yl-propyl)-amine(86684-07-3)
• EPA Substance Registry System: 3-Phenyl-isoxazol-5-yl-(3-piperidin-1-yl-propyl)-amine(86684-07-3)

Safety Data

• Hazardous Substances Data: 86684-07-3(Hazardous Substances Data)

Upstream product

• 3529-08-6 1-(3-aminopropyl)piperidine 
• 31329-61-0 3-chloro-5-phenylisoxazole 
• 109-72-8 n-butyllithium 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 3356-89-6 3-phenyl-5-chloroisoxazole 

Relevant articles and documents

Thrombin receptor antagonists

A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic am

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

The synthesis and biological evaluation of a series of nonpeptidic small molecule antagonists of the human platelet thrombin receptor (PAR-1) are described. Optimization of the 5-amino-3-arylisoxazole lead resulted in an approximate 100-fold increase in potency. The most potent of these compounds (54) inhibits platelet activation with IC50s of 90 nM against the thrombin receptor agonist peptide (TRAP) and 510 nM against thrombin as the agonist. Further, antagonist 54 fully blocks platelet aggregation stimulated by 1 nM thrombin for 10 min.