86685-95-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-CHLORO-PHENYL)-ISOXAZOL-5-YLAMINE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential to contribute to the development of new drugs. Its chemical structure allows for the creation of molecules with specific therapeutic properties, making it valuable in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(3-CHLORO-PHENYL)-ISOXAZOL-5-YLAMINE is utilized as a precursor in the production of pesticides and other crop protection agents. Its reactivity and structural features enable the design of effective compounds aimed at enhancing crop yields and protecting them from pests and diseases.
Used in Drug Discovery and Development:
3-(3-CHLORO-PHENYL)-ISOXAZOL-5-YLAMINE is employed as a potential candidate in drug discovery and development due to its demonstrated biological activities. Researchers leverage its properties to explore its efficacy in treating various diseases and conditions, underlining its importance in the advancement of medical treatments.
Safety Considerations:
Given its classification as a hazardous substance, 3-(3-CHLORO-PHENYL)-ISOXAZOL-5-YLAMINE requires special attention to safety during its production, use, and disposal. Appropriate safety protocols, including the use of personal protective equipment, handling procedures, and waste management strategies, must be strictly followed to mitigate risks to human health and the environment.

Upstream product

• 21667-62-9 3-chlorobenzoylacetonitrile 

Relevant academic research and scientific papers

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is

CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (Formula (I))

WNT PATHWAY MODULATORS

The present invention relates to dihydropyrazolo[l,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.